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KMID : 0603820120180030260
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Journal of Experimental & Biomedical Science
2012 Volume.18 No. 3 p.260 ~ p.267
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Comparison of Echocardiogram and Clinical Profile between Metabolically Healthy Obese (MHO) and Non Metabolically Healthy Obese (Non-MHO) Subjects
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Hong Seung-Bok
Shin Kyung-A
Choi Wan-Soo
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Abstract
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Obesity is associated with cardiovascular risk factors, such as dyslipidemia, hypertension and diabetes. However the presence of the obesity related deranged metabolic profiles varies widely among obese individuals. These individuals, known as "metabolically healthy obese phenotype (MHO)", despite having excessive body fatness, display favorable metabolic profiles characterized by insulin sensitivity, no hypertension, as well as less dyslipidemia, less inflammation. The purpose of this study was to compare cardiac characterization and clinical profile of MHO and Non-MHO (nonmetabolically healthy obese) subjects in men. We measured treadmill exercise capacity (METs) and maximum blood pressure (BP) in 210 subjects through a medical checkup at J General Hospital. Metabolic syndrome was defined according to the modified Adult Treatment Panel III definition criteria. Both MHO and Non-MHO subjects showed statistically significant changes in the left ventricular mass index (P<.001, P<.01, respectively), A-velocity (P<.01, P<.001, respectively), E/A ratio (P<.01, P<.001, respectively), E"-velocity (P<.001, P<.001, respectively), HOMA-IR (P<.01, P<.001, respectively) and maximum systolic BP (P<.01, respectively) compared with the MH-NO (metabolically healthy non obese) subjects. In conclusion, MHO participants were at increased risk of cardiovascular disease and partly metabolic disorder.
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KEYWORD
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Metabolically Healthy Obese (MHO), Iinsulin sensitivity, Echocardiogram, Clinical profile
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